Mr. Sultan Mohammed, a Class of 2013 D.M.D. student at the Boston University Henry M. Goldman School of Dental Medicine (GSDM), was recently honored at the Hinman Symposium in Memphis Tennessee. Mr. Mohammed won the Most Outstanding Presentation in Clinical Research award for his poster “Upregulation of Cthrc1 N-glycoprotein Marks OSCC Tumor Spread.”
Mr. Mohammed worked in the laboratory under the mentorship of Dr. Maria A. Kukuruzinska, Associate Dean for Research at GSDM. He worked through two APEX rotations and participated in the Intensive Research Program (IRP), researching the molecular mechanisms that underlie oral cancer progression.
“The work I presented investigated the role of N-glycosylation on the planar cell polarity pathway in oral squamous cell carcinoma (OSCC),” Mohammed said regarding his winning poster. “We found that the cthrc1, a glycoprotein which promotes the planar cell polarity pathway by stabilizing some of its components, was upregulated in OSCC. Additionally, our results show that the N-glycosylation status of cthrc1 is increased. These results suggest that in OSCC the planar cell polarity pathway is affected by aberrant N-glycosylation.”
“We are very proud that our pre-doctoral research students continue to contribute to advances in dental medicine and the scholarly mission of the GSDM,” said Dr. Kukuruzinska.