The International and American Associations for Dental Research (IADR/AADR) recently published two studies in the Journal of Dental Research (JDR).
In a report on a preclinical investigation titled “Flagellin Enhances Saliva IgA Response and Protection of Anti-Caries DNA Vaccine,” lead author Dr. Wei Shi, Wuhan Institute of Virology, Chinese Academy of Sciences, and his team of researchers demonstrate that anti-caries DNA vaccines, including pGJA-P/VAX, are promising for preventing dental caries. However, challenges remain because of the low immunogenicity of DNA vaccines.
“This investigation highlights the exciting potential of using vaccines to protect against dental caries,” said Dr. William V. Giannobile, JDR Editor-in-Chief. “This research is promising and provides optimism to help promote public health of caries-susceptible individuals.”
In a study titled “MicroRNA Modulation in Obesity and Periodontitis,” lead author Dr. Romina Perri, University of North Carolina at Chapel Hill School of Dentistry, conducted a pilot investigation to determine whether obesity or periodontal disease modified microRNA expression and whether there was any potential interaction between obesity and periodontitis that could involve microRNA modulation.
“The expression of specific microRNA species in obesity provides new insight into possible mechanisms of how risk factors might modify periodontal inflammation and may represent novel therapeutic targets,” said Dr. Giannobile.