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Scientist Discovers Natural Mechanism to Help Prevent Gum Disease

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Scientist Discovers Natural Mechanism to Help Prevent Gum Disease

A University of Louisville (UofL) School of Dentistry scientist has found a way to prevent inflammation and bone loss surrounding the teeth by blocking a natural signaling pathway of the enzyme GSK3b, which plays an important role in directing the immune response.

The discovery of UofL School of Dentistry researcher David Scott, Ph.D., and his team was published on-line first in the journal Molecular Medicine. The finding not only has implications in preventing periodontal disease, a chronic inflammatory disease that causes tooth loss, but also may have relevance to other chronic inflammatory diseases. Since GSK3b is involved in multiple inflammatory signaling pathways, it is associated with a number of diseases and also is being tested by scientists for its impact in Alzheimer’s disease, Type II diabetes and some forms of cancer, to name a few.

GSK3b is known to worsen the inflammation that occurs during bacterial infections. Blocking this enzyme from completing its normal function by using the GSK3-specific inhibitor, SB216763, stopped the inflammation process and subsequent bone loss induced by the key periodontal pathogen, P. gingivalis, Dr. Scott says.

The next step is for Dr. Scott and his team to determine whether SB216763 has any side-effects or whether they need to search for a different inhibitor of GSK3b. 

The article, Inhibition of GSK3 abolishes bacterial-induced periodontal bone loss in mice ” can be found on-line. 

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